Synaptic Plasticity in Pain

Synaptic Plasticity in Pain

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Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.... Zeilhofer HU (2006) Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor a3 subunit, which mediate ... Keller AF, Coull JA, Chery N, Poisbeau P, De Koninck Y (2001) Region-specific developmental specialization ofanbsp;...


Title:Synaptic Plasticity in Pain
Author: Marzia Malcangio
Publisher:Springer Science & Business Media - 2009-05-28
ISBN-13:

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